
Intentional overdose has been noted to be relatively rare a 25-year long survey involving 2 tertiary care centers with toxicology services reported a total of 22 intentional overdoses in adults. Toxicity can occur due to intentional overdose, unintentional overdose, and pediatric ingestion. They are one hundred times more potent than warfarin. Superwarfarins are now also used as pesticides and should be recognized as having potential to cause warfarin toxicity. While it was initially marketed as a rodenticide, it has been used as a medication for more than a half-century. 2019 doi:10.1038/s41599-0.Warfarin is a vitamin K antagonist used as an anticoagulant used for treatment and prevention of a variety of coagulopathic and thromboembolic disorders. Clinical model for predicting warfarin sensitivity.

National Institutes of Health Office of Dietary Supplements. Mechanisms and interactions in concomitant use of herbs and warfarin therapy: An updated review. Risks and prevention of bleeding with oral anticoagulants. Agency for Healthcare Research and Quality.

Your doctor might prescribe a shorter acting blood thinner (heparin) while you're not taking warfarin. You might need to decrease or stop your warfarin dose at least five days before surgery. Share this information even before minor procedures, such as vaccinations and routine dental cleanings.

Ask if you need testing to see if a new medication affects your warfarin treatment.

Tell your health care provider about all medications, herbal remedies or supplements you take.To reduce the risk of a bleeding event from warfarin treatment, follow these guidelines:
